Botox has become a household name, but it’s not the only option when it comes to achieving smoother skin and reducing the appearance of fine lines. There are multiple brands of what are collectively known as neuromodulators, all designed to relax muscles and soften wrinkles. While these products share a common goal, they differ in subtle ways that can influence which one is best for you.
The primary active ingredient in all neuromodulators is botulinum toxin type A, a purified protein that temporarily blocks nerve signals to muscles, reducing their activity. This works to smooth dynamic wrinkles—those caused by repetitive facial movements like frowning or squinting.
Despite the shared ingredient, each brand uses a slightly different formulation, leading to variations in how quickly they take effect, how long they last, and even how they’re stored and administered.
In the United States, the FDA has approved five neuromodulator brands for cosmetic use:
Each brand has its unique features and benefits, which we’ll break down in detail to help you better understand how they compare and which might be the right fit for your cosmetic goals.
As the original and most recognized botulinum toxin, Botox Cosmetic has set the standard for neuromodulators since its FDA approval in 2002. Manufactured by Allergan, now part of AbbVie, it’s backed by decades of research and clinical use. Known for its consistency and reliability, it remains a popular choice for smoothing wrinkles and achieving a more youthful appearance.
Botox Cosmetic is FDA-approved to treat moderate to severe frown lines (glabellar lines), crow’s feet, and forehead lines. Beyond cosmetic use, it’s also effective for medical conditions such as migraines, excessive sweating, and muscle spasms. For cosmetic applications, Botox works by relaxing the underlying muscles that cause dynamic wrinkles, resulting in smoother skin.
Results from Botox injections typically begin to appear within 3 to 7 days, with full effects visible at around two weeks. These effects generally last 3 to 4 months, depending on factors like individual metabolism and the treated area. Regular maintenance sessions are recommended to sustain results.
Botox Cosmetic’s long-standing reputation is built on extensive clinical studies and consistent results. Its formulation includes preservatives that ensure stability and effectiveness, making it a trusted option for patients and providers alike. It’s ideal for those looking for predictable outcomes with a well-established product.
Botox is considered safe and minimally invasive, but temporary side effects can occur. These may include mild redness, bruising, or swelling at the injection site, which typically resolve quickly. With proper application by a skilled provider, complications are rare.
Daxxify is the newest addition to the lineup of FDA-approved neuromodulators, offering a longer-lasting alternative for reducing wrinkles and fine lines. Manufactured by Revance Therapeutics, it was approved in 2022 and has quickly gained attention for its unique peptide-enhanced formula. This innovation sets it apart from other botulinum toxin treatments by extending its effects well beyond the typical duration.
Daxxify is FDA-approved for treating moderate to severe frown lines (glabellar lines). Like other neuromodulators, it relaxes the muscles responsible for dynamic wrinkles, creating a smoother and more refreshed appearance. Its extended longevity makes it particularly appealing to those seeking fewer treatments per year.
One of Daxxify’s standout features is its duration of effects. Results typically begin to appear within 3 to 7 days, similar to other neuromodulators. However, the effects can last up to 6 months for many patients and even up to 9 months for some, depending on individual factors. This makes it a game-changer for those looking for long-term results with fewer appointments.
Daxxify uses a proprietary peptide-enhanced formulation that allows it to bind more effectively to the targeted muscles, prolonging its effects. Unlike most other neuromodulators, it does not contain human serum albumin, which may appeal to patients seeking a vegan-friendly option. Its extended duration makes it an excellent choice for those who want to minimize the frequency of treatments without compromising results.
Daxxify shares a similar safety profile to other botulinum toxin products, with mild and temporary side effects being the most common. These include redness, swelling, or bruising at the injection site. Rarely, patients may experience headaches or eyelid drooping, but these risks are minimized when the treatment is administered by a skilled provider.
Xeomin is often referred to as the “pure” botulinum toxin, thanks to its unique formulation that excludes accessory proteins found in other neuromodulators. Manufactured by Merz Pharmaceuticals, Xeomin received FDA approval in 2010 and has become a popular choice for patients seeking a simpler, straightforward option for reducing wrinkles.
Xeomin is FDA-approved for treating moderate to severe frown lines (glabellar lines). Like its counterparts, it works by relaxing the muscles that cause dynamic wrinkles, smoothing the skin and giving it a refreshed appearance. Its pure formulation reduces the risk of the body developing antibodies that might make the treatment less effective over time.
Results from Xeomin injections typically begin to appear within 3 to 7 days, with full effects visible in about two weeks. Its effects generally last around 3 to 4 months, similar to Botox Cosmetic and Dysport. Patients who maintain regular treatments often find it delivers consistent and reliable results.
Xeomin is the only neuromodulator that is free of accessory proteins. This means it contains only the active botulinum toxin molecule, which some believe may lower the likelihood of resistance developing in long-term users. Its simplified formulation makes it an appealing option for patients who may have experienced a reaction to accessory proteins in other neuromodulators, offering a more purified alternative.
Xeomin has a safety profile similar to other botulinum toxin treatments. Temporary side effects may include mild redness, swelling, or bruising at the injection site. Rarely, patients might experience headaches or drooping in the treated area, but these risks are minimized when Xeomin is administered by a trained professional.
Dysport is a trusted neuromodulator known for its ability to diffuse more broadly, making it an excellent choice for treating larger areas or achieving a more natural, softer look. Manufactured by Ipsen, Dysport has been FDA-approved for cosmetic use since 2009 and is a favorite among both patients and providers for its fast onset and subtle results.
Dysport is FDA-approved for treating moderate to severe frown lines (glabellar lines). Like other botulinum toxin products, it works by temporarily relaxing the muscles responsible for dynamic wrinkles. Its unique formulation allows it to spread more easily, which can be particularly beneficial for addressing larger treatment areas.
Dysport’s results often appear faster than those of other neuromodulators, typically within 2 to 3 days, with full effects visible in about a week. Its duration is similar to Botox Cosmetic and Xeomin, lasting around 3 to 4 months. Many patients appreciate the quicker onset, especially if they’re preparing for a special event.
One of Dysport’s key differentiators is its ability to diffuse more broadly. This makes it a go-to option for larger treatment areas, such as the forehead, or for achieving a softer, more natural look in smaller areas. Its formulation contains fewer protein variations, which some believe may make it work faster for certain individuals. Providers often recommend Dysport for patients who want noticeable but subtle results.
Dysport’s side effects are generally mild and temporary, including redness, swelling, or bruising at the injection site. As with other neuromodulators, rare side effects like headaches or drooping can occur, but these risks are minimized with skilled application.
Jeuveau, often referred to as “Newtox,” is a modern neuromodulator offering a high-quality, affordable alternative for smoothing wrinkles. Manufactured by Evolus and approved by the FDA in 2019, Jeuveau is designed for anyone seeking effective wrinkle reduction, regardless of age. While it’s been heavily marketed to younger audiences, including millennials exploring early-stage wrinkle treatments, Jeuveau is equally effective for individuals of all ages looking to maintain or restore a smooth, refreshed appearance.
Jeuveau is FDA-approved for treating moderate to severe frown lines (glabellar lines). Like other botulinum toxin type A products, it works by relaxing the facial muscles responsible for dynamic wrinkles, helping to smooth the skin and prevent lines from becoming deeper over time.
Results from Jeuveau typically begin to appear within 3 to 7 days, with full effects visible in about two weeks. Its effects last around 3 to 4 months, comparable to Botox Cosmetic, Dysport, and Xeomin. Regular treatments help maintain results and prevent new wrinkles from forming.
Jeuveau has positioned itself as a youthful and modern alternative to other neuromodulators. With sleek branding and a price point often lower than Botox, it appeals to budget-conscious patients and those trying neuromodulators for the first time. While it uses the same botulinum toxin molecule as Botox, Jeuveau is manufactured using a proprietary process, giving it its own unique characteristics. Its effectiveness and affordability make it a strong choice for patients of all ages.
Jeuveau shares a similar safety profile to other neuromodulators, with common side effects including mild redness, swelling, or bruising at the injection site. Rarely, patients may experience temporary headaches or drooping in the treated area. These risks are minimized when Jeuveau is administered by a trained professional.
At ZENA Aesthetics & Wellness, we prioritize treatments that deliver reliable, proven results for our patients. That’s why we consistently recommend Botox Cosmetic and Dysport as our neuromodulators of choice.
Botox Cosmetic is the most established and widely recognized brand in the market. As the original FDA-approved neuromodulator, it has been extensively studied and consistently delivers predictable, high-quality results. Over the years, our patients have experienced excellent outcomes with Botox, making it a trusted favorite in our practice. Additionally, we participate in the Allē Rewards Program, allowing patients to earn points for their Botox treatments that can be redeemed for discounts on future services.
Similarly, Dysport has a long-standing reputation for effectiveness, with over 15 years of use in the market. It offers results comparable to Botox and is particularly appreciated for its ability to spread smoothly, making it a great choice for certain treatment areas. Dysport has also been a consistent performer for our patients, offering excellent results and satisfaction. We are proud to participate in the ASPIRE Rewards Program, which lets patients earn points for their Dysport treatments to save on future sessions.
Having both options allows us to tailor treatments to each patient’s needs. While both products work similarly, individual responses can vary. Some patients may prefer one over the other based on their unique experience, and it’s valuable to have an alternative to provide the best possible outcome.
In addition to choosing the right product, the skill and experience of the injector play a vital role in achieving optimal results. At ZENA, our aesthetics injector, Dr. Inda Mowett, is a physician with over 20 years of expertise in aesthetics. Her deep understanding of facial anatomy and her commitment to patient goals ensure that every treatment is performed with precision and care.
Choosing between Botox and Dysport often comes down to personal preference and how your body responds to each product. Both are highly effective at reducing wrinkles and delivering a refreshed, youthful appearance.
Botox Cosmetic remains the gold standard, trusted for its consistent and predictable results. It’s an excellent choice for anyone seeking a proven treatment with a well-established safety profile.
Dysport, on the other hand, offers comparable results and is often favored for its ability to spread more broadly in certain areas, such as the forehead. This characteristic can create a softer, more natural look for some individuals.
Ultimately, the product you choose is less important than the expertise of your injector. With Dr. Inda Mowett’s extensive experience and personalized approach at ZENA Aesthetics & Wellness, you can feel confident that you’re in skilled hands, no matter which option you select.
The best type of Botox or neuromodulator depends on your individual needs, goals, and how your body responds. Botox Cosmetic is often considered the gold standard due to its long history, proven results, and broad recognition. Dysport is another excellent option, especially for larger treatment areas or a softer look. A consultation with your injector can help determine the best choice for you.
While most neuromodulators, including Botox Cosmetic, Dysport, Xeomin, and Jeuveau, last about 3 to 4 months, Daxxify is designed to last longer, with effects lasting up to 6 months or even 9 months in some cases. However, individual factors like metabolism and the treated area can impact how long the results last.
Neither Botox nor Dysport is inherently better—it depends on your personal preferences and how your body responds. Botox is the most established brand and offers consistent results, while Dysport spreads more easily, making it a good choice for larger areas like the forehead. Your provider’s expertise will also play a significant role in achieving your desired outcome.
Achieving natural-looking results depends more on the injector’s skill than the specific product. With an experienced provider like Dr. Inda Mowett, who has over 20 years of expertise in aesthetics, both Botox Cosmetic and Dysport can deliver subtle, natural results that enhance your appearance without looking “frozen.”
If you stop receiving Botox treatments, your muscles will gradually regain their normal activity. Over time, wrinkles that were previously softened may reappear, but they won’t be worse than they were before treatment. In fact, regular Botox use can help prevent deeper wrinkles from forming, so stopping treatments simply means your skin will resume its natural aging process.
Botox results can be affected by improper aftercare, such as lying down or exercising vigorously within the first 4-6 hours after treatment. Excessive sun exposure, frequent facial massages, or using certain skincare products too soon (like retinoids) may also impact results. Always follow your injector’s aftercare instructions to ensure the best outcome.
When performed skillfully, Botox should look natural, making it difficult to detect. Common signs of poorly done Botox may include a “frozen” appearance, uneven eyebrows, or overly smooth skin that lacks expression. A skilled injector will focus on subtle enhancements that maintain a natural look.
For those seeking alternatives to Botox Cosmetic, Daxxify, Dysport, Xeomin, and Jeuveau are all FDA-approved neuromodulators that work similarly to Botox. We offer Dysport in addition to Botox Costmetic in our clinic. For non-injectable options, treatments like microneedling, laser resurfacing, or high-quality skincare products with peptides or retinoids can also improve skin texture and reduce the appearance of wrinkles.
Several factors can help prolong the effects of Botox. Protecting your skin from excessive sun exposure and using sunscreen daily can prevent premature breakdown of the product. Staying well-hydrated and maintaining a healthy lifestyle also contribute to longer-lasting results. Using gentle skincare products and avoiding harsh exfoliants near the treated area can help preserve the effects. Additionally, scheduling regular maintenance treatments ensures consistent outcomes over time.
Yes, vitamin C can be used after Botox, but it’s best to wait at least 24-48 hours before applying it. This gives the treated area time to settle and reduces the risk of irritation. Vitamin C serums are great for brightening and supporting overall skin health alongside Botox treatments.
An exclusive, clinically proven line of daily-use, anti-aging skincare products formulated with patented Trihex Technology® to promote fresh collagen and elastin production, protecting and renewing skin for a youthful appearance and faster satisfaction with treatment results.
Experience the Benefits Today